Cytotoxic Arylnaphthalene Lignans From Phyllanthus Oligospermus

Chem Pharm Bull (Tokyo). 2006 Aug;54(8):1223-5. doi: 10.1248/cpb.54.1223.

Abstract

Three new arylnaphthalene lignans, namely phyllanthusmins A-C, together with nine known compounds were isolated and characterized from the stems and roots of Phyllanthus oligospermus by a bioassay-guided purification. The structures of the new compounds were elucidated by means of spectroscopic data interpretation. Among them, phyllanthusminA displayed significant cytotoxicity against KB and P-388 cancer cell lines.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Benzodioxoles / chemistry*
  • Benzodioxoles / pharmacology*
  • Benzofurans / chemistry*
  • Benzofurans / pharmacology*
  • Cell Line, Tumor
  • Cell Survival / drug effects
  • Drug Screening Assays, Antitumor
  • Glycosides / chemistry*
  • Glycosides / pharmacology*
  • Humans
  • Inhibitory Concentration 50
  • Lignans / chemistry*
  • Molecular Structure
  • Naphthalenes / chemistry*
  • Phyllanthus / chemistry*
  • Plant Preparations / chemistry
  • Spectrum Analysis

Substances

  • Benzodioxoles
  • Benzofurans
  • Glycosides
  • Lignans
  • Naphthalenes
  • Plant Preparations
  • phyllanthusmin A
  • phyllanthusmin B
  • phyllanthusmin C