Abstract
We studied the effects of total sleep deprivation and recovery sleep in normal subjects using position emission tomography with 18F-deoxyglycose. Sleep deprivation resulted in a significant decrease in relative metabolism of the frontal cortex, thalamus, and striatum. Recovery sleep was found to have only a partial restorative effect on frontal lobe function with minimal reversal of subcortical deficits. Sleep may be especially important for maintenance of frontal lobe activity.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Adult
-
Brain Mapping
-
Cognition / physiology
-
Cognition Disorders / etiology
-
Cognition Disorders / metabolism
-
Cognition Disorders / physiopathology
-
Corpus Striatum / diagnostic imaging
-
Corpus Striatum / metabolism
-
Corpus Striatum / physiopathology
-
Energy Metabolism / physiology*
-
Female
-
Frontal Lobe / diagnostic imaging
-
Frontal Lobe / metabolism*
-
Frontal Lobe / physiopathology
-
Functional Laterality / physiology
-
Humans
-
Male
-
Middle Aged
-
Neuropsychological Tests
-
Positron-Emission Tomography
-
Recovery of Function / physiology*
-
Sleep / physiology*
-
Sleep Deprivation / diagnostic imaging
-
Sleep Deprivation / metabolism*
-
Sleep Deprivation / physiopathology
-
Thalamus / diagnostic imaging
-
Thalamus / metabolism
-
Thalamus / physiopathology