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. 2006 Dec;31(12):2783-92.
doi: 10.1038/sj.npp.1301166. Epub 2006 Jul 26.

Frontal Lobe Metabolic Decreases With Sleep Deprivation Not Totally Reversed by Recovery Sleep

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Frontal Lobe Metabolic Decreases With Sleep Deprivation Not Totally Reversed by Recovery Sleep

Joseph C Wu et al. Neuropsychopharmacology. .
Free article

Abstract

We studied the effects of total sleep deprivation and recovery sleep in normal subjects using position emission tomography with 18F-deoxyglycose. Sleep deprivation resulted in a significant decrease in relative metabolism of the frontal cortex, thalamus, and striatum. Recovery sleep was found to have only a partial restorative effect on frontal lobe function with minimal reversal of subcortical deficits. Sleep may be especially important for maintenance of frontal lobe activity.

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