Baseline health-related quality of life in the management of prostate cancer

Int J Urol. 2006 Jul;13(7):920-5. doi: 10.1111/j.1442-2042.2006.01441.x.


Objective: The purpose of this study was to clarify characteristics of baseline health-related quality of life (HRQOL) during the diagnostic process of prostate cancer.

Methods: A prospective study was conducted to measure HRQOL in a cohort of 141 patients in whom prostate cancer was suspected and prostate biopsy was scheduled, using both generic and disease-specific HRQOL measures (SF-36, UCLA-Prostate Cancer Index) at two points: before prostate biopsy (prediagnosis) and after giving biopsy results (postdiagnosis). Seventy-three patients were diagnosed with prostate cancer and 68 were not.

Results: Compared to age-gender adjusted population norms, patients demonstrated better physical function (PF) and worse mental health (MH). Characteristic age-related changes were found in PF and sexual function (SXF); however, disease stage exhibited no relevant effects in HRQOL. No significant difference was detected between pre- and postdiagnosis SF-36 and UCLA-PCI scores.

Conclusion: The present study discovered no relevant impact of the diagnostic process of prostate cancer on baseline HRQOL using SF-36 and UCLA-PCI. Combined with results of previous studies, it is supportive of regarding pretreatment levels of HRQOL as the baseline.

Publication types

  • Comparative Study

MeSH terms

  • Aged
  • Biopsy
  • Follow-Up Studies
  • Health Status
  • Humans
  • Male
  • Middle Aged
  • Prognosis
  • Prospective Studies
  • Prostatic Neoplasms / pathology
  • Prostatic Neoplasms / psychology*
  • Quality of Life*
  • Surveys and Questionnaires