Comparison of the EUCAST-AFST broth dilution method with the CLSI reference broth dilution method (M38-A) for susceptibility testing of posaconazole and voriconazole against Aspergillus spp

Clin Microbiol Infect. 2006 Sep;12(9):901-4. doi: 10.1111/j.1469-0691.2006.01419.x.


The susceptibilities of 40 clinical isolates of Aspergillus spp. (Aspergillus fumigatus, Aspergillus flavus, Aspergillus niger, Aspergillus terreus) were determined for posaconazole and voriconazole by the CLSI M38-A and EUCAST-AFST broth dilution methods. Where a discrepancy was observed between the methods, the EUCAST method tended to give higher MIC values. Overall, the level of agreement was 92.5% and the intra-class correlation coefficient was > 0.90.

Publication types

  • Comparative Study
  • Evaluation Study

MeSH terms

  • Antifungal Agents / pharmacology*
  • Aspergillus / classification
  • Aspergillus / drug effects*
  • Humans
  • Microbial Sensitivity Tests / methods
  • Pyrimidines / pharmacology*
  • Triazoles / pharmacology*
  • Voriconazole


  • Antifungal Agents
  • Pyrimidines
  • Triazoles
  • posaconazole
  • Voriconazole