Clinical inquiries. Which medications can be split without compromising efficacy and safety?

J Fam Pract. 2006 Aug;55(8):707-8.


Split tablets of lisinopril are as effective as whole tablets of the same dose for hypertension (strength of recommendation [SOR]: B, based on small randomized crossover study). Similarly, split tablets of atorvastatin, lovastatin, and simvastatin are no less effective for lowering cholesterol (SOR: B, based on retrospective cohort studies). Extended-release, enteric-coated, or tablets that cannot be split accurately are not appropriate for splitting (SOR: C, based on observational studies); the accuracy of splitting also depends on device used and user skill (SOR: C, based on observational study).

Publication types

  • Review

MeSH terms

  • Clinical Trials as Topic
  • Cost Savings
  • Drug Compounding* / economics
  • Drug Costs*
  • Humans
  • Tablets / administration & dosage*
  • Tablets / economics


  • Tablets