Isolation and insecticidal/anthelmintic activity of xanthonol, a novel bis-xanthone, from a non-sporulating fungal species

John G Ondeyka; Anne W Dombrowski; Jon P Polishook; Tom Felcetto; Wesley L Shoop; Ziqiang Guan; Sheo B Singh

doi:10.1038/ja.2006.40

Isolation and insecticidal/anthelmintic activity of xanthonol, a novel bis-xanthone, from a non-sporulating fungal species

J Antibiot (Tokyo). 2006 May;59(5):288-92. doi: 10.1038/ja.2006.40.

Authors

John G Ondeyka¹, Anne W Dombrowski, Jon P Polishook, Tom Felcetto, Wesley L Shoop, Ziqiang Guan, Sheo B Singh

Affiliation

¹ Merck Research Laboratories, Merck & Co., Inc. PO Box 2000, R80Y-355, Rahway, New Jersey 07065, USA. john_ondeyka@merck.com

PMID: 16883778
DOI: 10.1038/ja.2006.40

Abstract

Xanthonol, a novel dimeric xanthone, was isolated from a fermentation broth of a non-sporulating fungal species using Sephadex LH20 followed by HPLC and the structure elucidated by spectral analysis. Xanthonol exhibited insecticidal and anthelmintic activities against larvae of Lucilia sericata, Aedes aegypti, and Haemonchus contortus with LD90 of 33, 8, and 50 microg/ml, respectively.

MeSH terms

Anthelmintics / chemistry
Anthelmintics / isolation & purification*
Anthelmintics / pharmacology
Fungi / chemistry*
Gas Chromatography-Mass Spectrometry
Insecticides / chemistry
Insecticides / isolation & purification*
Insecticides / pharmacology
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Optical Rotation
Spectrometry, Mass, Electrospray Ionization
Xanthones / chemistry
Xanthones / isolation & purification*
Xanthones / pharmacology*

Substances

Anthelmintics
Insecticides
Xanthones
xanthonol