No ancillary finding is valid to distinguish a primary ovarian hepatoid carcinoma from metastatic hepatocellular carcinoma

Int J Gynecol Cancer. 2006 Jul-Aug;16(4):1691-4. doi: 10.1111/j.1525-1438.2006.00646.x.


Primary ovarian hepatoid carcinomas (POHC) are extremely rare. Especially rare are those with phenotypic properties of hepatocellular carcinoma (HCC) and an absence of clinical evidence of hepatic tumor. We report a case of a POHC with a common microscopic, immunophenotypic, and ultrastructural property of HCC in the absence of a liver mass. It is extremely difficult to differentiate POHC from metastatic HCC using any kinds of ancillary studies, with the exception of clinical identification of a hepatic tumor.

Publication types

  • Case Reports
  • Comparative Study

MeSH terms

  • Adult
  • Carcinoma, Hepatocellular / diagnosis*
  • Carcinoma, Hepatocellular / metabolism
  • Carcinoma, Hepatocellular / secondary
  • Diagnosis, Differential
  • Female
  • Humans
  • Liver Neoplasms / diagnosis*
  • Liver Neoplasms / metabolism
  • Liver Neoplasms / secondary
  • Ovarian Neoplasms / diagnosis*
  • Ovarian Neoplasms / metabolism
  • Ovarian Neoplasms / therapy
  • alpha-Fetoproteins / metabolism


  • alpha-Fetoproteins