Dynamic connectivity in the mitral cell-granule cell microcircuit

Semin Cell Dev Biol. 2006 Aug;17(4):424-32. doi: 10.1016/j.semcdb.2006.04.006. Epub 2006 May 5.


The interactions between excitatory mitral cells and inhibitory granule cells are critical for the regulation of olfactory bulb activity. Here we review anatomical and physiological data on the mitral cell-granule cell circuit and provide a quantitative estimate of how this connectivity varies as a function of distance between mitral cells. We also discuss the ways in which the functional connectivity can be altered rapidly during olfactory bulb activity.

Publication types

  • Review

MeSH terms

  • Animals
  • Dendrites / physiology
  • Humans
  • Models, Biological
  • Models, Neurological
  • Neuronal Plasticity / physiology*
  • Olfactory Bulb / anatomy & histology
  • Olfactory Bulb / cytology*
  • Olfactory Bulb / physiology*
  • Synapses / physiology*
  • Synaptic Transmission / physiology*