Abstract
Canonical Wnt signaling, below the Fz/LRP receptor complex, induces the stabilization of beta-catenin via an unresolved mechanism. A recent study in Genes & Development introduces a new player and deepens our understanding of this signaling relay that plays pivotal roles during embryogenesis and tumorigenesis.
MeSH terms
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Animals
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Frizzled Receptors / metabolism
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Humans
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LDL-Receptor Related Proteins / metabolism
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Microfilament Proteins / genetics
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Microfilament Proteins / metabolism*
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Models, Biological
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Signal Transduction / genetics
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Signal Transduction / physiology*
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Wnt Proteins / genetics
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Wnt Proteins / metabolism*
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beta Catenin / metabolism
Substances
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Frizzled Receptors
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LDL-Receptor Related Proteins
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Microfilament Proteins
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Wnt Proteins
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beta Catenin