Impulsivity and BOLD fMRI activation in MDMA users and healthy control subjects

Psychiatry Res. 2006 Oct 30;147(2-3):239-42. doi: 10.1016/j.pscychresns.2006.01.014. Epub 2006 Aug 4.


The correlation between scores on the Barratt Impulsiveness Scale (BIS) and activation measured by functional magnetic resonance imaging in a dorsolateral prefrontal cortical (DLPFC) activating task was examined in 15 MDMA-using subjects and 19 controls. A significant correlation between BIS scores and DLPFC activation was found, supporting a role for the DLPFC in BIS-measured impulsivity.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Adult
  • Brain / metabolism*
  • Hallucinogens*
  • Health Status*
  • Humans
  • Impulsive Behavior / epidemiology*
  • Impulsive Behavior / psychology*
  • Magnetic Resonance Imaging*
  • N-Methyl-3,4-methylenedioxyamphetamine*
  • Prefrontal Cortex / metabolism
  • Substance-Related Disorders / epidemiology*
  • Substance-Related Disorders / metabolism*


  • Hallucinogens
  • N-Methyl-3,4-methylenedioxyamphetamine