Impulsivity and BOLD fMRI activation in MDMA users and healthy control subjects

Ignacio H Valdes; Joel L Steinberg; Ponnada A Narayana; Larry A Kramer; Donald M Dougherty; Alan C Swann; Ernest S Barratt; Frederick Gerard Moeller

doi:10.1016/j.pscychresns.2006.01.014

Impulsivity and BOLD fMRI activation in MDMA users and healthy control subjects

Psychiatry Res. 2006 Oct 30;147(2-3):239-42. doi: 10.1016/j.pscychresns.2006.01.014. Epub 2006 Aug 4.

Authors

Ignacio H Valdes¹, Joel L Steinberg, Ponnada A Narayana, Larry A Kramer, Donald M Dougherty, Alan C Swann, Ernest S Barratt, Frederick Gerard Moeller

Affiliation

¹ Department of Psychiatry and Behavioral Sciences, University of Texas Health Science Center at Houston, 1300 Moursund, Houston, TX 77030, USA. ivaldes@hal-pc.org

PMID: 16890410
DOI: 10.1016/j.pscychresns.2006.01.014

Abstract

The correlation between scores on the Barratt Impulsiveness Scale (BIS) and activation measured by functional magnetic resonance imaging in a dorsolateral prefrontal cortical (DLPFC) activating task was examined in 15 MDMA-using subjects and 19 controls. A significant correlation between BIS scores and DLPFC activation was found, supporting a role for the DLPFC in BIS-measured impulsivity.

Publication types

Research Support, N.I.H., Extramural

MeSH terms

Adult
Brain / metabolism*
Hallucinogens*
Health Status*
Humans
Impulsive Behavior / epidemiology*
Impulsive Behavior / psychology*
Magnetic Resonance Imaging*
N-Methyl-3,4-methylenedioxyamphetamine*
Prefrontal Cortex / metabolism
Substance-Related Disorders / epidemiology*
Substance-Related Disorders / metabolism*

Substances

Hallucinogens
N-Methyl-3,4-methylenedioxyamphetamine

Abstract

Publication types

MeSH terms

Substances

Grants and funding