Regulation of Fli1 gene expression and lupus

Autoimmun Rev. 2006 Jul;5(6):377-82. doi: 10.1016/j.autrev.2005.10.005. Epub 2005 Dec 13.

Abstract

Ets transcription factors function throughout development in such varied processes as cellular proliferation, apoptosis, differentiation and migration. Many have been implicated to play important roles in hematopoiesis, vasculogenesis/angiogenesis and myogenesis. Fli1 is an Ets family member that is essential for development and increasing evidence suggests modulating Fli1 gene expression impacts lymphocyte function and is important in the autoimmune disease lupus. Presently, it is unknown how Fli1 gene expression is controlled in lymphocytes. Identifying upstream regulators of Fli1 in lymphocytes will be critical for understanding lymphocyte development and the consequences of dysregulation and may be of value in developing future treatments for lupus.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Base Sequence
  • Binding Sites
  • GATA Transcription Factors / genetics
  • Gene Expression Regulation*
  • Humans
  • Lupus Erythematosus, Systemic / genetics*
  • Lupus Erythematosus, Systemic / metabolism
  • Mice
  • Mice, Inbred BALB C
  • Microfilament Proteins / genetics*
  • Microfilament Proteins / metabolism
  • Molecular Sequence Data
  • Promoter Regions, Genetic
  • Receptors, Cytoplasmic and Nuclear / genetics*
  • Receptors, Cytoplasmic and Nuclear / metabolism
  • STAT Transcription Factors / genetics
  • Sequence Homology, Nucleic Acid
  • Transcription, Genetic*

Substances

  • FLII protein, human
  • GATA Transcription Factors
  • Microfilament Proteins
  • Receptors, Cytoplasmic and Nuclear
  • STAT Transcription Factors