Relationship between metabolic syndrome and familial history of hypertension/stroke, diabetes, and cardiovascular disease

J Korean Med Sci. 2006 Aug;21(4):701-8. doi: 10.3346/jkms.2006.21.4.701.


This research analyzes the prevalence of metabolic syndrome (MS) in Korea and examines how the presence of a familial history of diseases related to MS, such as hypertension/stroke, cardiovascular disease, and diabetes, affect the development of MS in Koreans. The prevalence of MS and its components, as defined by the Nation-al Cholesterol Education Program Adult Treatment Panel guidelines, were evaluated in nationally representative samples of non-institutionalized civilian Koreans. This analysis is based on the 2001 Korea National Health and Nutrition Examination Survey, which used a stratified multistage probability sampling design. The final study included 5,742 adults who had completed the necessary health examinations and met the diagnosis of MS. The prevalence of MS was 25.5% in men and 28.7% in women. Odds ratio for MS among men with a familial history of hypertension/stroke was higher than that among men who did not have this history. The OR for MS among women with a familial history of hypertension/stroke or diabetes was higher than that among women who had no familial history of these diseases. These results show that familial history of hypertension/stroke and diabetes was significantly related to the presence of MS in both young men and women.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Age Distribution
  • Age Factors
  • Aged
  • Cardiovascular Diseases / genetics*
  • Diabetes Mellitus / genetics*
  • Family Health
  • Female
  • Genetic Predisposition to Disease / genetics*
  • Humans
  • Hypertension / genetics*
  • Korea / epidemiology
  • Male
  • Metabolic Syndrome / epidemiology
  • Metabolic Syndrome / genetics*
  • Middle Aged
  • Odds Ratio
  • Prevalence
  • Sex Factors
  • Stroke / genetics*