Memory T(H)2 cells induce alternatively activated macrophages to mediate protection against nematode parasites

Nat Med. 2006 Aug;12(8):955-60. doi: 10.1038/nm1451. Epub 2006 Jul 30.

Abstract

Although primary and memory responses against bacteria and viruses have been studied extensively, T helper type 2 (T(H)2) effector mechanisms leading to host protection against helminthic parasites remain elusive. Examination of the intestinal epithelial submucosa of mice after primary and secondary infections by a natural gastrointestinal parasite revealed a distinct immune-cell infiltrate after challenge, featuring interleukin-4-expressing memory CD4(+) T cells that induced IL-4 receptor(hi) (IL-4R(hi)) CD206(+) alternatively activated macrophages. In turn, these alternatively activated macrophages (AAMacs) functioned as important effector cells of the protective memory response contributing to parasite elimination, demonstrating a previously unknown mechanism for host protection against intestinal helminths.

Publication types

  • Comparative Study

MeSH terms

  • Adoptive Transfer
  • Animals
  • Arginase / antagonists & inhibitors
  • Boronic Acids / pharmacology
  • CD4-Positive T-Lymphocytes / physiology
  • CD4-Positive T-Lymphocytes / transplantation
  • Electron Transport Complex IV / metabolism
  • Enzyme Inhibitors / pharmacology
  • Female
  • Host-Parasite Interactions
  • Immunohistochemistry
  • Injections, Intravenous
  • Interleukin-4 / genetics
  • Larva / enzymology
  • Larva / parasitology
  • Macrophages / immunology*
  • Mice
  • Mice, Inbred BALB C
  • Mice, Knockout
  • Nematoda / immunology*
  • Nematoda / physiology
  • Nematode Infections / immunology*
  • Nematode Infections / parasitology
  • STAT6 Transcription Factor / genetics
  • Strongylida Infections / immunology*
  • Strongylida Infections / parasitology
  • Th2 Cells / immunology*

Substances

  • (2-boronoethyl)-cysteine
  • Boronic Acids
  • Enzyme Inhibitors
  • STAT6 Transcription Factor
  • Interleukin-4
  • Electron Transport Complex IV
  • Arginase