Modulators of the kynurenine pathway of tryptophan metabolism: synthesis and preliminary biological evaluation of (S)-4-(ethylsulfonyl)benzoylalanine, a potent and selective kynurenine aminotransferase II (KAT II) inhibitor

ChemMedChem. 2006 May;1(5):528-31. doi: 10.1002/cmdc.200500095.
No abstract available

MeSH terms

  • Aminobutyrates / chemical synthesis*
  • Aminobutyrates / pharmacology*
  • Animals
  • Enzyme Inhibitors / chemical synthesis*
  • Enzyme Inhibitors / pharmacology*
  • Kynurenine / metabolism*
  • Rats
  • Sulfones / chemical synthesis*
  • Sulfones / pharmacology*
  • Transaminases / antagonists & inhibitors*
  • Tryptophan / metabolism*

Substances

  • 4-(ethylsulfonyl)benzoylalanine
  • Aminobutyrates
  • Enzyme Inhibitors
  • Sulfones
  • Kynurenine
  • Tryptophan
  • Transaminases
  • kynurenine-oxoglutarate transaminase