Streptococcus Pneumoniae Protein Vaccine Candidates: Properties, Activities and Animal Studies

Crit Rev Microbiol. 2006;32(3):139-53. doi: 10.1080/10408410600822942.

Abstract

Streptococcus pneumoniae is a causative agent for community acquired pneumonia, bacteremia, acute otitis media, and meningitis. Recent emergence of multi-drug resistant clinical isolates prompts the need of effective vaccine for the prevention of disease. The licensed polysaccharide-based pneumococcal vaccines only elicit protective antibodies against the infection of serotypes that are included in the vaccine. To broaden the protection, the use of pneumococcal proteins will be a feasible and preferable alternative. This communication provides a review on the biochemical properties of these protein candidates, their immunization results in animal studies, and perspectives on the development of protein-based pneumococcal vaccine.

Publication types

  • Review

MeSH terms

  • Adhesins, Bacterial / administration & dosage
  • Adhesins, Bacterial / immunology
  • Animals
  • Bacterial Proteins / administration & dosage*
  • Bacterial Proteins / immunology
  • Bacterial Vaccines / administration & dosage
  • Disease Models, Animal
  • Lipoproteins / administration & dosage
  • Lipoproteins / immunology
  • N-Acetylmuramoyl-L-alanine Amidase / administration & dosage
  • N-Acetylmuramoyl-L-alanine Amidase / immunology
  • Neuraminidase / administration & dosage
  • Neuraminidase / immunology
  • Pneumococcal Infections / prevention & control*
  • Pneumococcal Vaccines / administration & dosage
  • Streptococcus pneumoniae / chemistry*
  • Streptolysins / administration & dosage
  • Streptolysins / immunology

Substances

  • Adhesins, Bacterial
  • Bacterial Proteins
  • Bacterial Vaccines
  • Lipoproteins
  • Pneumococcal Vaccines
  • PsaA protein, Streptococcus
  • Streptolysins
  • plY protein, Streptococcus pneumoniae
  • pneumococcal surface protein A
  • Neuraminidase
  • N-Acetylmuramoyl-L-alanine Amidase