Lyssavirus infection activates interferon gene expression in the brain

J Gen Virol. 2006 Sep;87(Pt 9):2663-7. doi: 10.1099/vir.0.82024-0.

Abstract

To investigate the innate immune response within the brain to lyssavirus infection, key transcripts indicative of innate defences were measured in a mouse model system. Following infection with Rabies virus, transcript levels for type 1 interferons (IFN-alpha and -beta), the inflammatory mediator interleukin 6 (IL-6) and the antiviral protein Mx1 increased in the brains of mice. Intracranial inoculation resulted in the early detection of virus replication and rapid expression within the brain of the innate immune response genes. Transcripts for type 1 IFNs declined as the disease progressed. Peripheral, extraneural inoculation delayed the host response until virus entered the brain, but then resulted in a large increase in the level of IFN-beta, IL-6 and Mx1 transcripts. Induction of this response was also observed following infection with the related European bat lyssaviruses, a group of zoonotic viruses capable of causing fatal, rabies-like disease in mammalian species.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Brain / immunology*
  • Chiroptera / virology
  • GTP-Binding Proteins / genetics
  • Gene Expression Regulation
  • Immunity, Innate
  • Interferon-alpha / genetics*
  • Interferon-beta / genetics*
  • Interleukin-6 / genetics
  • Lyssavirus / immunology
  • Lyssavirus / pathogenicity*
  • Lyssavirus / physiology
  • Mice
  • Myxovirus Resistance Proteins
  • RNA / genetics
  • RNA / metabolism
  • Rabies / genetics
  • Rabies / immunology
  • Rabies / virology
  • Rabies virus / immunology
  • Rabies virus / pathogenicity
  • Rabies virus / physiology
  • Rhabdoviridae Infections / genetics*
  • Rhabdoviridae Infections / immunology*
  • Rhabdoviridae Infections / virology
  • Virus Replication

Substances

  • Interferon-alpha
  • Interleukin-6
  • Mx1 protein, mouse
  • Myxovirus Resistance Proteins
  • RNA
  • Interferon-beta
  • GTP-Binding Proteins