Sensing by bacterial regulatory systems in host and non-host environments

Nat Rev Microbiol. 2006 Sep;4(9):705-9. doi: 10.1038/nrmicro1478. Epub 2006 Aug 7.


Free-living organisms have the ability to gauge their surroundings and modify their gene expression patterns in ways that help them cope with new environments. Here we discuss the physiological significance of recent reports describing the ability of the Salmonella typhimurium PhoP/PhoQ two-component system to recognize and respond to host-derived antimicrobial peptides.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Antimicrobial Cationic Peptides / metabolism*
  • Bacterial Physiological Phenomena
  • Bacterial Proteins / genetics
  • Bacterial Proteins / metabolism*
  • Gene Expression Regulation, Bacterial*
  • Humans
  • Salmonella typhimurium / genetics*
  • Salmonella typhimurium / physiology*
  • Signal Transduction


  • Antimicrobial Cationic Peptides
  • Bacterial Proteins
  • PhoQ protein, Bacteria
  • PhoP protein, Bacteria