Mechanisms of Multidrug Resistance in Acinetobacter Species and Pseudomonas Aeruginosa

Clin Infect Dis. 2006 Sep 1;43 Suppl 2:S49-56. doi: 10.1086/504477.

Abstract

Acinetobacter species and Pseudomonas aeruginosa are noted for their intrinsic resistance to antibiotics and for their ability to acquire genes encoding resistance determinants. Foremost among the mechanisms of resistance in both of these pathogens is the production of beta -lactamases and aminoglycoside-modifying enzymes. Additionally, diminished expression of outer membrane proteins, mutations in topoisomerases, and up-regulation of efflux pumps play an important part in antibiotic resistance. Unfortunately, the accumulation of multiple mechanisms of resistance leads to the development of multiply resistant or even "panresistant" strains.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Acinetobacter / drug effects*
  • Acinetobacter / enzymology
  • Acinetobacter / genetics
  • Aminoglycosides / metabolism
  • Cross Infection / drug therapy
  • Drug Resistance, Multiple, Bacterial / drug effects
  • Drug Resistance, Multiple, Bacterial / genetics*
  • Humans
  • Membrane Transport Proteins / drug effects
  • Membrane Transport Proteins / genetics
  • Porins / drug effects
  • Porins / genetics
  • Pseudomonas aeruginosa / drug effects*
  • Pseudomonas aeruginosa / enzymology
  • Pseudomonas aeruginosa / genetics
  • Quinolones / pharmacology
  • beta-Lactamases / genetics
  • beta-Lactamases / metabolism

Substances

  • Aminoglycosides
  • Membrane Transport Proteins
  • Porins
  • Quinolones
  • beta-Lactamases