This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features!

Skip to main page content

Email citation

Add to Collections

Your saved search

Name of saved search:

Search terms:

Test search terms

Would you like email updates of new search results?

Yes
No

Email: (change)

Frequency:

Which day?

Which day?

Report format:

Send at most:

Send even when there aren't any new results

Optional text in email:

Your RSS Feed

Review

. 2006 Aug;106(8):3468-96.

doi: 10.1021/cr0503097.

Assembly-line enzymology for polyketide and nonribosomal Peptide antibiotics: logic, machinery, and mechanisms

Michael A Fischbach¹, Christopher T Walsh

Affiliations

PMID: 16895337
DOI: 10.1021/cr0503097

Review

Assembly-line enzymology for polyketide and nonribosomal Peptide antibiotics: logic, machinery, and mechanisms

Michael A Fischbach et al. Chem Rev. 2006 Aug.

. 2006 Aug;106(8):3468-96.

doi: 10.1021/cr0503097.

Authors

Michael A Fischbach¹, Christopher T Walsh

Affiliation

¹ Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA.

PMID: 16895337
DOI: 10.1021/cr0503097

No abstract available

PubMed Disclaimer

Similar articles

Chapter 9. Synthetic probes for polyketide and nonribosomal peptide biosynthetic enzymes.
Meier JL, Burkart MD. Meier JL, et al. Methods Enzymol. 2009;458:219-54. doi: 10.1016/S0076-6879(09)04809-5. Methods Enzymol. 2009. PMID: 19374985
Polyketide and nonribosomal peptide antibiotics: modularity and versatility.
Walsh CT. Walsh CT. Science. 2004 Mar 19;303(5665):1805-10. doi: 10.1126/science.1094318. Science. 2004. PMID: 15031493 Review.
Evolution and taxonomic distribution of nonribosomal peptide and polyketide synthases.
Amoutzias GD, Van de Peer Y, Mossialos D. Amoutzias GD, et al. Future Microbiol. 2008 Jun;3(3):361-70. doi: 10.2217/17460913.3.3.361. Future Microbiol. 2008. PMID: 18505401 Review.
Computational structural enzymology methodologies for the study and engineering of fatty acid synthases, polyketide synthases and nonribosomal peptide synthetases.
Schaub AJ, Moreno GO, Zhao S, Truong HV, Luo R, Tsai SC. Schaub AJ, et al. Methods Enzymol. 2019;622:375-409. doi: 10.1016/bs.mie.2019.03.001. Epub 2019 Apr 22. Methods Enzymol. 2019. PMID: 31155062 Free PMC article.
[Biologically active nonribosomal peptides. III. Mechanism of biosynthesis of nonribosomal peptides].
Orlova TI, Bulgakova VG, Polin AN. Orlova TI, et al. Antibiot Khimioter. 2012;57(7-8):43-54. Antibiot Khimioter. 2012. PMID: 23350194 Review. Russian.

See all similar articles

Cited by

Engineering of a Peptide α-N-Methyltransferase to Methylate Non-Proteinogenic Amino Acids.
Song H, Burton AJ, Shirran SL, Fahrig-Kamarauskaitė J, Kaspar H, Muir TW, Künzler M, Naismith JH. Song H, et al. Angew Chem Weinheim Bergstr Ger. 2021 Jun 21;133(26):14440-14444. doi: 10.1002/ange.202100818. Epub 2021 May 17. Angew Chem Weinheim Bergstr Ger. 2021. PMID: 38505374 Free PMC article.
A meta-analysis of the gut microbiome in inflammatory bowel disease patients identifies disease-associated small molecules.
Elmassry MM, Sugihara K, Chankhamjon P, Camacho FR, Wang S, Sugimoto Y, Chatterjee S, Chen LA, Kamada N, Donia MS. Elmassry MM, et al. bioRxiv [Preprint]. 2024 Feb 8:2024.02.07.579278. doi: 10.1101/2024.02.07.579278. bioRxiv. 2024. PMID: 38370680 Free PMC article. Preprint.
Exploring the substrate stereoselectivity and catalytic mechanism of nonribosomal peptide macrocyclization in surugamides biosynthesis.
Du Z, Ma Y, Shen Y, Jiang X, Zhou Y, Shi T. Du Z, et al. iScience. 2024 Jan 11;27(2):108876. doi: 10.1016/j.isci.2024.108876. eCollection 2024 Feb 16. iScience. 2024. PMID: 38313049 Free PMC article.
PEARL-catalyzed peptide bond formation after chain reversal during the biosynthesis of non-ribosomal peptides.
Yu Y, van der Donk WA. Yu Y, et al. bioRxiv [Preprint]. 2023 Dec 23:2023.12.23.573212. doi: 10.1101/2023.12.23.573212. bioRxiv. 2023. PMID: 38187666 Free PMC article. Preprint.
Genomic Characterization of the Mycoparasite Pestalotiopsis sp. Strain cr013 from Cronartium ribicola.
Yu J, Kong L, Fan S, Li M, Li J. Yu J, et al. Pol J Microbiol. 2023 Dec 16;72(4):433-442. doi: 10.33073/pjm-2023-041. eCollection 2023 Dec 1. Pol J Microbiol. 2023. PMID: 38095159 Free PMC article.

See all "Cited by" articles

Publication types

Actions
Actions
Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions

Substances

Actions
Actions
Actions
Actions

Grants and funding

LinkOut - more resources

Full Text Sources
- American Chemical Society
Other Literature Sources
- The Lens - Patent Citations
Medical
- MedlinePlus Health Information
Molecular Biology Databases
- BioCyc