The anaphase promoting complex/cyclosome: a machine designed to destroy

Nat Rev Mol Cell Biol. 2006 Sep;7(9):644-56. doi: 10.1038/nrm1988. Epub 2006 Aug 9.


The anaphase promoting complex/cyclosome (APC/C) is a ubiquitin ligase that has essential functions in and outside the eukaryotic cell cycle. It is the most complex molecular machine that is known to catalyse ubiquitylation reactions, and it contains more than a dozen subunits that assemble into a large 1.5-MDa complex. Recent discoveries have revealed an unexpected multitude of mechanisms that control APC/C activity, and have provided a first insight into how this unusual ubiquitin ligase recognizes its substrates.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Anaphase-Promoting Complex-Cyclosome
  • Animals
  • Catalytic Domain / physiology
  • Humans
  • Multienzyme Complexes / metabolism*
  • Protein Processing, Post-Translational / physiology*
  • Substrate Specificity / physiology
  • Ubiquitin / metabolism*
  • Ubiquitin-Protein Ligase Complexes / genetics
  • Ubiquitin-Protein Ligase Complexes / metabolism*


  • Multienzyme Complexes
  • Ubiquitin
  • Ubiquitin-Protein Ligase Complexes
  • Anaphase-Promoting Complex-Cyclosome