A randomized clinical multicentre trial comparing enamel matrix derivative and membrane treatment of buccal class II furcation involvement in mandibular molars. Part III: patient factors and treatment outcome

J Clin Periodontol. 2006 Aug;33(8):575-83. doi: 10.1111/j.1600-051X.2006.00947.x.


Objective: Evaluation of effects of patient factors on the outcome of regenerative treatment of buccal mandibular class II furcation defects.

Material and methods: Fifty-one patients were recruited. In the intention-to-treat population 21 patients were allocated into the sequence left treatment with enamel matrix protein derivative (EMD) and right guided tissue regeneration (GTR) and 27 in the sequence left GTR and right EMD. Evaluated patient factors were: smoking, age, gender, hypertension and oral hygiene status. Outcome parameters included change of: (a) horizontal depth of the defect at the deepest point (b) distance from the fornix of the furcation to bone crest of the defect, (c) distance from stent to the bottom of the defect, (d) pocket depth and (e) attachment level at the middle of the furcation.

Results: In patients 54 years of age and older, in males, in non-smokers and in patients with "poor" hygiene EMD-treated sites showed a significant higher mean reduction of the parameters d (age), b (gender, hygiene) a (smoking, hygiene) when compared with sites treated with GTR.

Conclusions: These data provided an indication of a possible effect of patient factors on the outcome of regenerative treatment of buccal mandibular class II furcation defects.

Publication types

  • Multicenter Study
  • Randomized Controlled Trial

MeSH terms

  • Age Factors
  • Alveolar Process / pathology
  • Biocompatible Materials / therapeutic use*
  • Bone Regeneration / physiology
  • Dental Enamel Proteins / therapeutic use*
  • Female
  • Furcation Defects / classification
  • Furcation Defects / surgery*
  • Guided Tissue Regeneration, Periodontal*
  • Humans
  • Hypertension / physiopathology
  • Male
  • Mandible
  • Membranes, Artificial*
  • Middle Aged
  • Molar / surgery*
  • Oral Hygiene
  • Periodontal Attachment Loss / classification
  • Periodontal Pocket / classification
  • Polyglactin 910 / therapeutic use
  • Sex Factors
  • Smoking / physiopathology
  • Treatment Outcome


  • Biocompatible Materials
  • Dental Enamel Proteins
  • Membranes, Artificial
  • Resolut
  • enamel matrix proteins
  • Polyglactin 910