Mannan-binding lectin in asthma and allergy

Curr Allergy Asthma Rep. 2006 Sep;6(5):377-83. doi: 10.1007/s11882-996-0007-6.


Mannan-binding lectin (MBL) is a vital and versatile component of innate immunity. It is present in serum and may bind to a plethora of microbial pathogens and mediate opsonization of these by complement-dependent and/or independent mechanisms. Low-MBL levels in serum, attributed to certain genetic polymorphisms, constitute a major factor predisposing to several infectious diseases. However, recent studies propose that MBL extends beyond its classic role as a first-line host-defense molecule to a modulator of inflammation. In this review, we summarize and explore this potential and a possible novel role of MBL in asthma and allergy.

Publication types

  • Review

MeSH terms

  • Animals
  • Aspergillus fumigatus / immunology
  • Asthma / immunology*
  • Disease Models, Animal
  • Humans
  • Hypersensitivity / immunology*
  • Mannose-Binding Lectin / immunology*
  • Polymorphism, Genetic


  • Mannose-Binding Lectin