The long and the short of it: relational memory impairments in amnesia, even at short lags

J Neurosci. 2006 Aug 9;26(32):8352-9. doi: 10.1523/JNEUROSCI.5222-05.2006.


Classic studies of amnesia led to characterizations of hippocampal function emphasizing involvement in long-term memory rather than short-term (or working) memory. In two experiments, we show that when memory for relations among co-occurring items is tested, hippocampal amnesia results in a deficit even at very short lags. Hence, we find evidence for hippocampal involvement in relational memory, even at short lags normally considered the province of working memory.

Publication types

  • Randomized Controlled Trial
  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Amnesia / complications
  • Amnesia / physiopathology*
  • Association Learning*
  • Cognition Disorders / complications
  • Cognition Disorders / physiopathology*
  • Female
  • Hippocampus / physiopathology*
  • Humans
  • Male
  • Memory, Short-Term*
  • Psychomotor Performance*
  • Space Perception*
  • Time Factors