Stridor in Crohn disease and the use of infliximab

Chest. 2006 Aug;130(2):579-81. doi: 10.1378/chest.130.2.579.


Extraintestinal manifestations of Crohn disease are well recognized. Upper airway obstruction is a very rare but important complication that usually responds to high-dose steroids. We report a case of Crohn disease initially presenting with respiratory symptoms and subsequently resulting in acute severe upper airway obstruction, which failed to respond to steroids but dramatically responded to the first documented use of infliximab in this context.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Airway Obstruction / diagnosis
  • Airway Obstruction / drug therapy
  • Airway Obstruction / etiology*
  • Antibodies, Monoclonal / therapeutic use*
  • Bronchoscopy
  • Crohn Disease / complications*
  • Crohn Disease / drug therapy
  • Crohn Disease / physiopathology
  • Diagnosis, Differential
  • Female
  • Follow-Up Studies
  • Gastrointestinal Agents / therapeutic use*
  • Humans
  • Infliximab
  • Respiratory Sounds / diagnosis*
  • Respiratory Sounds / physiopathology
  • Tomography, X-Ray Computed


  • Antibodies, Monoclonal
  • Gastrointestinal Agents
  • Infliximab