Caffeine inhibits forskolin-stimulated cyclic AMP accumulation in rat brain

Eur J Pharmacol. 1990 Jan 10;175(2):203-5. doi: 10.1016/0014-2999(90)90231-t.

Abstract

Caffeine potently inhibited forskolin-stimulated cyclic AMP accumulation in slices of rat cerebral cortex. The IC50 for this inhibition was 21 +/- 2.9 microM, and 200 microM caffeine almost completely blocked the forskolin response. Theophylline which is a behavioural stimulant mimicked the effect of caffeine. However, there was only a slight inhibition of the forskolin response by theobromine and IBMX (3-isobutyl-1-methylxanthine), both of which lack behavioral stimulant effects.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • 1-Methyl-3-isobutylxanthine / pharmacology
  • Animals
  • Brain / metabolism*
  • Caffeine / pharmacology*
  • Cerebral Cortex / metabolism
  • Colforsin / antagonists & inhibitors
  • Colforsin / pharmacology*
  • Cyclic AMP / metabolism*
  • Male
  • Rats
  • Rats, Inbred Strains
  • Theobromine / pharmacology
  • Theophylline / pharmacology

Substances

  • Colforsin
  • Caffeine
  • Theophylline
  • Cyclic AMP
  • Theobromine
  • 1-Methyl-3-isobutylxanthine