Use of ethanol-induced tumor necrosis to palliate dysphagia in patients with esophagogastric cancer

Gastrointest Endosc. Jan-Feb 1990;36(1):43-6. doi: 10.1016/s0016-5107(90)70921-2.

Abstract

Eleven patients with dysphagia caused by inoperable, unresectable, or recurrent esophagogastric cancer were treated by endoscopic injection of ethanol (with or without per-oral dilation) to induce tumor necrosis. Prior to treatment, patients had a mean dysphagia grade of 3. After one treatment, dysphagia grade had improved to a mean of 1.5. An optimum dysphagia grade (mean, 0.9) was achieved after a mean of 1.6 injection treatments. Treatments were repeated as symptoms recurred, with a mean period between repeat treatments of 32 days (median, 26). There were no complications associated with ethanol-induced tumor necrosis (ETN). Mean patient survival was 140 days (median, 109). These results suggest that ETN has considerable potential for palliation of malignant dysphagia in selected patients.

MeSH terms

  • Aged
  • Aged, 80 and over
  • Deglutition Disorders / therapy*
  • Esophageal Neoplasms / complications*
  • Esophageal Neoplasms / pathology
  • Esophagoscopy
  • Ethanol / administration & dosage*
  • Female
  • Gastroscopy
  • Humans
  • Male
  • Middle Aged
  • Necrosis / chemically induced
  • Palliative Care*
  • Sclerosing Solutions
  • Stomach Neoplasms / complications*
  • Stomach Neoplasms / pathology

Substances

  • Sclerosing Solutions
  • Ethanol