A new, efficient, and simple method for the one-pot synthesis of alpha-acetoxyphosphonates from aldehydes under solvent-free conditions

Babak Kaboudin; Masoumeh Karimi

doi:10.1016/j.bmcl.2006.07.083

A new, efficient, and simple method for the one-pot synthesis of alpha-acetoxyphosphonates from aldehydes under solvent-free conditions

Bioorg Med Chem Lett. 2006 Oct 15;16(20):5324-7. doi: 10.1016/j.bmcl.2006.07.083. Epub 2006 Aug 9.

Authors

Babak Kaboudin¹, Masoumeh Karimi

Affiliation

¹ Department of Chemistry, Institute for Advanced Studies in Basic Sciences (IASBS), Gava Zang, Zanjan 45195-1159, Iran. kaboudin@iasbs.ac.ir

PMID: 16901691
DOI: 10.1016/j.bmcl.2006.07.083

Abstract

A simple, efficient, and new method has been developed for the synthesis of alpha-acetoxyphosphonates from aldehydes through a one-pot reaction of aldehydes with diethylphosphite in the presence of acetic anhydride under solvent-free conditions using magnesium oxide. This method is easy, rapid, and high yielding for the one-pot synthesis of alpha-acetoxyphosphonates from aldehydes.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aldehydes / chemistry*
Magnesium Oxide / chemistry
Molecular Structure
Organophosphonates / chemical synthesis*
Organophosphonates / chemistry

Substances

Aldehydes
Organophosphonates
Magnesium Oxide