Rough Sheets and Smooth Tubules

Cell. 2006 Aug 11;126(3):435-9. doi: 10.1016/j.cell.2006.07.019.

Abstract

The endoplasmic reticulum (ER) has distinct morphological domains composed of sheets and tubules, which differ in their characteristic membrane curvature. Key proteins may drive the formation of these structural morphologies, which in turn could generate the rough and smooth functional domains of the ER.

Publication types

  • Review

MeSH terms

  • Animals
  • Cytoplasmic Vesicles / metabolism
  • Cytoplasmic Vesicles / ultrastructure
  • Endoplasmic Reticulum, Rough / metabolism*
  • Endoplasmic Reticulum, Rough / ultrastructure*
  • Endoplasmic Reticulum, Smooth / metabolism*
  • Endoplasmic Reticulum, Smooth / ultrastructure*
  • Humans
  • Intracellular Membranes / metabolism
  • Intracellular Membranes / ultrastructure
  • Microtubules / metabolism
  • Microtubules / ultrastructure
  • Protein Biosynthesis / physiology
  • Protein Transport / physiology
  • Ribosomes / genetics
  • Ribosomes / metabolism
  • Steroids / biosynthesis

Substances

  • Steroids