Boning up on ephrin signaling

Gregory R Mundy; Florent Elefteriou

doi:10.1016/j.cell.2006.07.015

Boning up on ephrin signaling

Cell. 2006 Aug 11;126(3):441-3. doi: 10.1016/j.cell.2006.07.015.

Authors

Gregory R Mundy¹, Florent Elefteriou

Affiliation

¹ Vanderbilt Center for Bone Biology, Vanderbilt University Medical Center, Nashville, TN, USA. gregory.r.mundy@vanderbilt.edu

PMID: 16901775
DOI: 10.1016/j.cell.2006.07.015

Abstract

The activities of osteoclasts, which degrade bone, and osteoblasts, which form bone, are coordinated to maintain bone homeostasis. Zhao et al. (2006) now demonstrate bidirectional signaling between these two cell populations via the transmembrane ligand ephrinB2 expressed by osteoclasts and its receptor EphB4 expressed by osteoblasts. Such bidirectional signaling limits osteoclast activity while stimulating osteoblast differentiation.

Publication types

Comment
Review

MeSH terms

Animals
Bone Remodeling / physiology
Bone and Bones / cytology
Bone and Bones / metabolism*
Cell Communication / physiology
Cell Differentiation / physiology
Ephrin-B2 / metabolism*
Homeostasis / physiology
Humans
Osteoblasts / cytology
Osteoblasts / metabolism*
Osteoclasts / cytology
Osteoclasts / metabolism*
Osteogenesis / physiology
Receptor, EphB4 / metabolism*
Signal Transduction / physiology

Substances

Ephrin-B2
Receptor, EphB4