Community exposure to perfluorooctanoate: relationships between serum levels and certain health parameters

J Occup Environ Med. 2006 Aug;48(8):771-9. doi: 10.1097/01.jom.0000233380.13087.37.


Objective: The objective of this study was to determine whether certain biomarkers of toxicity and/or a past diagnosis of liver or thyroid disease were associated with serum perfluorooctanoate concentrations (PFOA) in a community with longstanding environmental exposure to PFOA.

Methods: Serum (PFOA), hematologic and biochemical biomarkers, and a questionnaire were administered to 371 residents selected by stratified random sampling and a lottery among volunteers. Median PFOA was 354 ng/mL (interquartile range, 181-571 ng/mL).

Results: No significant positive relationships between serum (PFOA) and liver or renal function tests, cholesterol, thyroid-stimulating hormone, or with red cell indices, white cell, or platelet counts. Mean serum (PFOA) was not increased in those with a history of liver or thyroid disease.

Conclusions: No toxicity from PFOA was demonstrated using the measured end points; other end points need to be addressed.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Caprylates / blood*
  • Caprylates / poisoning
  • Child
  • Child, Preschool
  • Environmental Exposure*
  • Environmental Monitoring / methods
  • Environmental Pollutants / blood*
  • Environmental Pollutants / poisoning
  • Female
  • Fluorocarbons / blood*
  • Fluorocarbons / poisoning
  • Health Status
  • Humans
  • Liver Diseases / blood
  • Male
  • Middle Aged
  • Residence Characteristics*
  • Thyroid Diseases / blood
  • West Virginia


  • Caprylates
  • Environmental Pollutants
  • Fluorocarbons
  • perfluorooctanoic acid