HIV-reverse transcriptase and human DNA polymerase alpha share amino acid sequence homologies to bacterial penicillin-binding proteins

Methods Find Exp Clin Pharmacol. Jan-Feb 1990;12(1):43-6.

Abstract

Penicillin-binding proteins are the specific targets for the beta-lactam antibiotics. Recently it was observed that beta-lactam antibiotics also have targets in proliferating eukaryotic cells (1), one of which most likely is the replicative DNA polymerase alpha. Here we show that HIV-reverse transcriptase and human DNA polymerase alpha share amino acid sequence homologies to five bacterial penicillin-binding proteins.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Bacterial Proteins / analysis*
  • Carrier Proteins / analysis*
  • DNA Polymerase II / analysis*
  • Escherichia coli / enzymology
  • HIV / enzymology*
  • Hexosyltransferases*
  • Humans
  • Molecular Sequence Data
  • Muramoylpentapeptide Carboxypeptidase / analysis*
  • Penicillin-Binding Proteins
  • Peptidyl Transferases*
  • RNA-Directed DNA Polymerase / analysis*
  • Sequence Homology, Nucleic Acid

Substances

  • Bacterial Proteins
  • Carrier Proteins
  • Penicillin-Binding Proteins
  • Peptidyl Transferases
  • Hexosyltransferases
  • RNA-Directed DNA Polymerase
  • DNA Polymerase II
  • Muramoylpentapeptide Carboxypeptidase