The regulation of allergy and asthma

Immunol Rev. 2006 Aug;212:238-55. doi: 10.1111/j.0105-2896.2006.00413.x.

Abstract

Allergic diseases and asthma are caused by exaggerated T-helper 2 (Th2)-biased immune responses in genetically susceptible individuals. Tolerance to allergens is a mechanism that normally prevents such responses, but the specific immunological events that mediate tolerance in this setting are poorly understood. A number of recent studies indicate that regulatory T cells (Tregs) play an important role in controlling such Th2-biased responses. Tregs involved in regulating allergy and asthma consist of a family of related types of T cells, including natural CD25+ Tregs as well as inducible forms of antigen-specific adaptive Tregs. Impaired expansion of natural and/or adaptive Tregs is hypothesized to lead to the development of allergy and asthma, and treatment to induce allergen-specific Tregs could provide curative therapies for these problems.

Publication types

  • Review

MeSH terms

  • Allergens / immunology
  • Animals
  • Asthma / immunology*
  • Asthma / therapy
  • Humans
  • Hypersensitivity / immunology*
  • Hypersensitivity / therapy
  • Immune Tolerance*
  • Immunosuppression
  • Killer Cells, Natural / immunology
  • Mice
  • T-Lymphocytes, Regulatory / immunology*
  • T-Lymphocytes, Regulatory / transplantation
  • Th2 Cells / immunology

Substances

  • Allergens