ERM proteins in epithelial cell organization and functions

Biochim Biophys Acta. 2007 May;1773(5):653-60. doi: 10.1016/j.bbamcr.2006.06.013. Epub 2006 Jul 10.

Abstract

ERM (Ezrin, Radixin, Moesin) proteins are membrane-cytoskeleton linkers that regulate the structure and the function of specific domains of the plasma membrane. ERM proteins are expressed in all metazoan analyzed so far. Genetic analysis of ERM protein functions has recently been performed simultaneously in three different organisms, mouse, Drosophila melanogaster and C. elegans. These studies have revealed a remarkable conservation of the protein functions through evolution. Moreover they have shed light on the crucial role these proteins play in various physiological processes that occur in epithelial cells.

Publication types

  • Review

MeSH terms

  • Animals
  • Caenorhabditis elegans / physiology
  • Cell Membrane / physiology*
  • Cytoskeletal Proteins / genetics
  • Cytoskeletal Proteins / metabolism*
  • Cytoskeleton / physiology*
  • Drosophila melanogaster / physiology
  • Epithelial Cells / physiology*
  • Membrane Proteins / genetics
  • Membrane Proteins / metabolism*
  • Mice
  • Microfilament Proteins / genetics
  • Microfilament Proteins / metabolism*

Substances

  • Cytoskeletal Proteins
  • Membrane Proteins
  • Microfilament Proteins
  • ezrin
  • moesin
  • radixin