Tacrolimus treatment for refractory lupus cystitis

Mod Rheumatol. 2006;16(4):264-6. doi: 10.1007/s10165-006-0494-2.


A 23-year-old woman presented with recurrence of lupus cystitis, which had been in remission under daily administration of a single corticosteroid over a period of 8 years. She was treated with increased doses of corticosteroid and immunosuppressants, i.e., cyclosporin, cyclophosphamide, azathioprine, and salazosulfapyridine, but the cystitis remained active. Since her condition became critical by the complication of intestinal pseudo-obstruction, tacrolimus was administered. This agent induced a remission promptly without significant adverse events in this patient, suggesting an efficacy to lupus cystitis refractory to corticosteroid and other immunosuppressants.

Publication types

  • Case Reports

MeSH terms

  • Adrenal Cortex Hormones / administration & dosage
  • Adult
  • Cystitis / diagnostic imaging
  • Cystitis / drug therapy*
  • Cystitis / etiology*
  • Female
  • Humans
  • Hydronephrosis / diagnostic imaging
  • Hydronephrosis / etiology
  • Immunosuppressive Agents / administration & dosage*
  • Intestinal Pseudo-Obstruction / diagnostic imaging
  • Intestinal Pseudo-Obstruction / etiology
  • Lupus Erythematosus, Systemic / complications*
  • Radiography
  • Tacrolimus / administration & dosage*
  • Ultrasonography


  • Adrenal Cortex Hormones
  • Immunosuppressive Agents
  • Tacrolimus