Platelet content and growth factor release in platelet-rich plasma: a comparison of four different systems

Vox Sang. 2006 Aug;91(2):135-9. doi: 10.1111/j.1423-0410.2006.00815.x.

Abstract

Background: Different systems for preparation of platelet-rich plasma are commercially available, but data for comparison of these systems have not been published so far.

Materials and methods: We investigated the performance of Vivostat PRF Preparation Kit, PCCS Platelet Concentrate Collection System, Harvest SmartPReP 2 APC 60 Process, and Fibrinet Autologous Fibrin & Platelet System. The preparations provided by these systems are platelet concentrates with high numbers of platelets in a small volume of plasma and PDGF-AB is released continuously during the 5 days after preparation.

Results: Vivostat PRF Preparation Kit, PCCS Platelet Concentrate Collection System, Harvest SmartPReP 2 APC 60 Process are comparable in platelet yield and total amount of released PDGF-AB after 120 h while with Fibrinet the lowest platelet yield and PDGF-AB content of supernatant was achieved. The ability of growth factor release was equal in all four systems.

Conclusion: In conclusion, all four systems for preparation of platelet-rich plasma investigated result in considerable growth factor release. In what extent the total content of PDGF-AB as a consequence of platelet yield has an impact on wound healing has to be further investigated.

Publication types

  • Comparative Study
  • Evaluation Study

MeSH terms

  • Blood Platelets / cytology
  • Blood Platelets / metabolism*
  • Humans
  • Platelet Count / methods*
  • Platelet-Derived Growth Factor / chemistry
  • Platelet-Derived Growth Factor / metabolism*
  • Plateletpheresis / methods*
  • Time Factors

Substances

  • Platelet-Derived Growth Factor
  • platelet-derived growth factor AB