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, 16 (21), 5621-4

Free Radical Scavengers From the Medicinal Mushroom Inonotus Xeranticus and Their Proposed Biogenesis

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Free Radical Scavengers From the Medicinal Mushroom Inonotus Xeranticus and Their Proposed Biogenesis

In-Kyoung Lee et al. Bioorg Med Chem Lett.

Abstract

New free radical scavengers, inoscavin D (1) and methylinoscavin D (2), were isolated from the methanolic extract of the fruiting bodies of Inonotus xeranticus (Hymenochaetaceae), along with the known compounds phelligridin D (3), 3,4-dihydroxybenzaldehyde (4), and 3,4-dihydroxybenzoic acid (5). Their structures were established by various spectroscopic analyses. Compounds 1 and 3 were proposed to be biosynthesized from the oxidative coupling of the precursor hispidin with 3,4-dihydroxybenzaldehyde and 3,4-dihydroxybenzoic acid, respectively. These compounds exhibited significant scavenging activity against the ABTS radical cation, and compounds 2 and 4 displayed moderate superoxide radical scavenging activity.

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