Histopathologic findings in primary erythromelalgia are nonspecific: special studies show a decrease in small nerve fiber density

J Am Acad Dermatol. 2006 Sep;55(3):519-22. doi: 10.1016/j.jaad.2006.04.067.


The histopathology of primary erythromelalgia has been poorly characterized. A total of 33 skin biopsy specimens from 29 patients with a diagnosis of primary erythromelalgia were re-examined. Histopathologic findings were nonspecific. Vascular thrombi were not identified. A relative decrease in small nerve fiber density was noted in specimens from 13 of 16 patients.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Biopsy
  • Erythromelalgia / pathology*
  • Female
  • Humans
  • Male
  • Microscopy, Confocal
  • Middle Aged
  • Nerve Fibers / pathology*
  • Skin / innervation*
  • Skin / pathology*