[Retrograde signaling in the GABA- and glutamatergic synapses of the brain]

Fiziol Zh. 2006;52(3):103-9.
[Article in Ukrainian]


According to classical concept, due to chemical synapses, information in the central nervous system is transferred in one direction: from presynaptic neurons to postsynaptic ones. Although several cases of information transfer in the opposite direction were known for a long time, those were considered as rare exceptions. However, recent results indicate that retrograde signaling between brain neurons is rather a common phenomenon. In this review we will focus on two related forms of short-term plasticity of GABAergic and glutamatergic synaptic transmission observed in several brain structures and mediated by retrograde messengers endocannabinoids. Namely, we will characterize phenomenon termed "depolarization-induced suppression of inhibition", observed at GABAergic synapses and related phenomenon observed at glutamatergic synapses named "depolarization-induced suppression of excitation".

Publication types

  • English Abstract
  • Review

MeSH terms

  • Animals
  • Brain / metabolism
  • Brain / physiology*
  • Cannabinoid Receptor Modulators / metabolism
  • Excitatory Postsynaptic Potentials / physiology
  • Humans
  • Neuronal Plasticity / physiology
  • Receptors, GABA / metabolism
  • Receptors, GABA / physiology*
  • Receptors, Glutamate / metabolism
  • Receptors, Glutamate / physiology*
  • Synaptic Transmission / physiology*


  • Cannabinoid Receptor Modulators
  • Receptors, GABA
  • Receptors, Glutamate