[Relationship between micro- and minisatellites in the human genome]

Biofizika. Jul-Aug 2006;51(4):650-5.
[Article in Russian]

Abstract

Micro- and minisatellites constitute an essential part of DNA with a low sequence complexity and carry several important functions. A search for tandem repeats in the human genome with a length of a repeat unit of up to 70 bp, including repeats with a great number of nucleotide substitutions, has been performed using the TaadeaSWAN program. It was shown that, for a considerable number of minisatellites with the length of the repeating unit of less than 25 nt, a shorter repeating motif can be distinguished in the sequence of this repeat, which often is similar to the sequence of minisatellites widely occurring in the human genome. A model of hierarchic origination of minisatellites in the human genome is suggested.

Publication types

  • English Abstract
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Evolution, Molecular*
  • Genome, Human / genetics*
  • Humans
  • Microsatellite Repeats / genetics*
  • Minisatellite Repeats / genetics*
  • Models, Genetic*
  • Software*