Carcinogenicity of 2-amino-3-methylimidazo[4,5-f]quinoline in nonhuman primates: induction of tumors in three macaques

Jpn J Cancer Res. 1990 Jan;81(1):10-4. doi: 10.1111/j.1349-7006.1990.tb02500.x.


The carcinogenic potential of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) was evaluated in cynomolgus monkeys. Monkeys received IQ, beginning at the age of one year, at doses of 10 or 20 mg/kg by gavage. Thus far, IQ has induced hepatocellular carcinoma in three monkeys with a latent period of 27 to 37 months. Metastases to the lung occurred in two of the three monkeys. Microscopically, the hepatocellular carcinoma in all three cases demonstrated a trabecular pattern. These data demonstrate that IQ is a potent carcinogen in nonhuman primates and support the idea that it is a potential carcinogen for humans.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Carcinogens*
  • Female
  • Liver / pathology
  • Liver Neoplasms, Experimental / chemically induced*
  • Liver Neoplasms, Experimental / pathology
  • Lung Neoplasms / secondary
  • Macaca fascicularis
  • Male
  • Quinolines / toxicity*
  • alpha-Fetoproteins / metabolism


  • Carcinogens
  • Quinolines
  • alpha-Fetoproteins
  • 2-amino-3-methylimidazo(4,5-f)quinoline