Direct Association of a Promoter Polymorphism in the CD36/FAT Fatty Acid Transporter Gene With Type 2 Diabetes Mellitus and Insulin Resistance

Diabet Med. 2006 Aug;23(8):907-11. doi: 10.1111/j.1464-5491.2006.01888.x.

Abstract

Aims: The membrane-bound fatty acid transporter CD36/FAT may play a role in disturbed fatty acid handling as observed in the metabolic syndrome and Type 2 diabetes mellitus (T2DM). Genetic variation in the CD36 gene may contribute to the aetiology of diabetes.

Methods: A population-based cohort in the Netherlands [age > 40 years and body mass index (BMI) > 25 kg/m2] of 675 subjects was phenotyped with respect to glucose metabolism with an oral glucose tolerance test and was genotyped for a known 478C-->T substitution and a C/T snp in the upstream promoter region (rs1527479) in the CD36 gene.

Results: T2DM was more prevalent in the TT genotype than in the CC genotype. This was most pronounced in women and in subjects with a high BMI (BMI > 27 kg/m2). In addition, within the group of diabetic patients, the TT genotype was commoner in subjects with increased homeostasis model assessment (HOMA) index for insulin resistance. The 478C-->T substitution, previously found in the Japanese population, was not found in our caucasian population.

Conclusions: This is the first study to show a direct association of a CD36 snp with T2DM. Moreover, within the diabetic subjects, this CD36 snp was associated with insulin resistance (HOMA index).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • CD36 Antigens / genetics*
  • Diabetes Mellitus, Type 2 / genetics*
  • Fatty Acids / genetics
  • Fatty Acids / metabolism*
  • Female
  • Humans
  • Insulin Resistance / genetics*
  • Lipid Metabolism / genetics
  • Male
  • Middle Aged
  • Netherlands
  • Obesity
  • Polymorphism, Genetic / genetics*

Substances

  • CD36 Antigens
  • Fatty Acids