Transfusion-related risks of intradermal allogeneic lymphocyte immunotherapy: single cases in a large cohort and review of the literature

Am J Reprod Immunol. 2006 Sep;56(3):157-71. doi: 10.1111/j.1600-0897.2006.00413.x.


Problem: Lymphocyte immunotherapy (LIT) is applied in infertility treatment. Moreover, it has been suggested for prevention of rhesus D-hemolytic disease and as a vaccine for reduction of human immunodeficiency virus-1 susceptibility. Although transfusion-related problems have been rarely reported they were a matter of debate. Here we discuss extensive single-center experience with intradermal LIT for implantation failure and recurrent miscarriages.

Method of study: Retrospective 2- to 3-year follow-up of in vitro fertilization couples treated during 1996-2002 (feedback 2,848/3,041 = 93%), registering 930 deliveries. Prospective survey for acute reactions for 2000-2003 (feedback 2,687/3,246 = 83%). Review of the literature.

Results: Infections of the patient and transplant rejection later in life are minor residual risks. Post-transfusion purpura was suspected once but not verified. Anaphylaxis or malignancy were not promoted. Fetal/newborn alloimmune disease (severe hemolytic disease, thrombocytopenia, neutropenia) were not observed.

Conclusion: Based on microbiological, immunological, and hematological testing the risks of intradermal LIT are low.

Publication types

  • Review

MeSH terms

  • Abortion, Habitual / immunology
  • Abortion, Habitual / therapy*
  • Female
  • Fertilization in Vitro
  • Humans
  • Immunotherapy*
  • Infertility / therapy*
  • Lymphocyte Transfusion / adverse effects*
  • Lymphocyte Transfusion / methods
  • Male
  • Meta-Analysis as Topic
  • Pregnancy