Opsoclonus-myoclonus as a manifestation of Lyme disease

J Neurol Neurosurg Psychiatry. 2006 Sep;77(9):1090-1. doi: 10.1136/jnnp.2006.091728.


Opsoclonus-myoclonus syndrome (OMS) is a rare condition that includes chaotic multidirectional saccadic eye movements associated with myoclonus and ataxia. In adults, it is usually considered to be an autoimmune disease occurring either in a paraneoplastic context or after central nervous system infection. We report the case of a patient who presented with the classic features of OMS as a manifestation of acute Borrelia burgdorferi infection that was shown both on serum and cerebrospinal fluid examination. The outcome was favourable after prolonged antibiotic treatment. Lyme disease could be added to the list of aetiologies to be screened in OMS, as it would allow effective treatment and avoidance of unnecessary investigations.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Anti-Bacterial Agents / therapeutic use
  • Humans
  • Lyme Disease / complications*
  • Lyme Disease / drug therapy
  • Male
  • Paraneoplastic Syndromes, Nervous System / etiology*


  • Anti-Bacterial Agents