Bacopa monniera extract reduces amyloid levels in PSAPP mice

J Alzheimers Dis. 2006 Aug;9(3):243-51. doi: 10.3233/jad-2006-9303.


PSAPP mice expressing the "Swedish" amyloid precursor protein and M146L presenilin-1 mutations are a well-characterized model for spontaneous amyloid plaque formation. Bacopa monniera has a long history of use in India as an anti-aging and memory-enhancing ethnobotanical therapy. To evaluate the effect of Bacopa monniera extract (BME) on amyloid (Abeta) pathology in PSAPP mice, two doses of BME (40 or 160 mg/kg/day) were administered starting at 2 months of age for either 2 or 8 months. Our present data suggests that BME lowers Abeta 1-40 and 1-42 levels in cortex by as much as 60%, and reverses Y-maze performance and open field hyperlocomotion behavioral changes present in PSAPP mice. The areas encompassed by Congo Red-positive fibrillar amyloid deposits, however, were not altered by BME treatment. The data suggest that BME has potential application in Alzheimer's disease therapeutics.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Amyloid / antagonists & inhibitors*
  • Amyloid / metabolism*
  • Amyloid beta-Protein Precursor / biosynthesis
  • Amyloid beta-Protein Precursor / genetics*
  • Animals
  • Bacopa / chemistry*
  • Behavior, Animal / drug effects
  • Body Weight / drug effects
  • Brain Chemistry / drug effects*
  • Cognition / drug effects
  • Dose-Response Relationship, Drug
  • Enzyme-Linked Immunosorbent Assay
  • Humans
  • Maze Learning / drug effects
  • Mice
  • Mice, Transgenic
  • Motor Activity / drug effects
  • Neurofibrils / drug effects
  • Neurofibrils / metabolism
  • Plant Extracts / pharmacology
  • Presenilin-1 / biosynthesis
  • Presenilin-1 / genetics


  • Amyloid
  • Amyloid beta-Protein Precursor
  • Plant Extracts
  • Presenilin-1