Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 9 (3 Suppl), 417-23

Consensus Guidelines for the Clinical and Pathologic Diagnosis of Dementia With Lewy Bodies (DLB): Report of the Consortium on DLB International Workshop


Consensus Guidelines for the Clinical and Pathologic Diagnosis of Dementia With Lewy Bodies (DLB): Report of the Consortium on DLB International Workshop

Ian G McKeith. J Alzheimers Dis.


Dementia with Lewy bodies (DLB) was considered to be an uncommon cause of dementia until improved neuropathological staining methods for ubiquitin were developed in the late 1980's. Subsequent recognition that 10-15% of dementia cases in older people were associated with Lewy body pathology led to the publication in 1996 of Consensus clinical and pathological diagnostic criteria for the disorder. These have greatly raised global awareness of DLB and helped to generate a body of knowledge which informs modern clinical management of this pharmacologically sensitive group of patients. They have also enabled important issues surrounding the relationships of DLB with Alzheimer's disease and Parkinson's disease to be addressed and partially resolved. A recent re-evaluation of the Consensus criteria has confirmed many aspects of the original recommendations, supplementing these with suggestions for improved pathological characterisation, clinical detection and management. Virtu-ally unrecognised 20 years ago, DLB could within this decade be one of the best characterised and potentially treatable neurodegenerative disorders of late life.

Similar articles

  • Are Dementia With Lewy Bodies and Parkinson's Disease Dementia the Same Disease?
    KA Jellinger et al. BMC Med 16 (1), 34. PMID 29510692.
    DLB and PDD are important dementia syndromes that overlap in many clinical features, genetics, neuropathology, and management. They are currently considered as subtypes o …
  • Dementia With Lewy Bodies
    D Weisman et al. Semin Neurol 27 (1), 42-7. PMID 17226740. - Review
    Synucleinopathies, with and without dementia, encompass a wide range of diseases including Parkinson's disease, multiple system atrophy, rapid eye movement (REM) sleep be …
  • Dementia With Lewy Bodies
    IG McKeith et al. Semin Clin Neuropsychiatry 8 (1), 46-57. PMID 12567332. - Review
    The objective was to summarize recent findings about the clinical features, diagnosis and investigation of dementia with Lewy (DLB) bodies, together with its neuropatholo …
  • Accuracy of Clinical Diagnosis of Dementia With Lewy Bodies Versus Neuropathology
    R Skogseth et al. J Alzheimers Dis 59 (4), 1139-1152. PMID 28731443.
    Our findings suggest that the international clinical consensus criteria for DLB perform reasonably well. However, false positive and false negative diagnoses still occur, …
  • Dementia With Lewy Bodies
    I McKeith et al. Lancet Neurol 3 (1), 19-28. PMID 14693108. - Review
    Dementia with Lewy bodies (DLB) is the second commonest cause of neurodegenerative dementia in older people. It is part of the range of clinical presentations that share …
See all similar articles

Cited by 146 PubMed Central articles

See all "Cited by" articles

Publication types

LinkOut - more resources