Characteristics at presentation and outcome of hepatocellular carcinoma (HCC) in the elderly. A study of the Cancer of the Liver Italian Program (CLIP)

Crit Rev Oncol Hematol. 2006 Sep;59(3):243-9. doi: 10.1016/j.critrevonc.2006.01.002. Epub 2006 Aug 17.


Purpose: To describe the characteristics at presentation and the outcome of elderly patients (> or =70 years old) with HCC, a retrospective analysis using a CLIP database was performed.

Patients and methods: The database included 650 patients. Chi2-test, logistic and Cox model were applied.

Results: Baseline characteristics and stage were similarly among elderly (n=158) and non-elderly (n=492) patients. More elderly patients did not receive any local treatment (56% versus 38%, p<0.0001). Age and CLIP score were independently predictive of the odds of locoregional treatment. Prognosis was worse for elderly patients with a hazard ratio of death of 1.49 (95% CI 1.20-1.86) at multivariable analysis. The survival difference disappeared when patients were compared within each treatment group, suggesting a close link between undertreatment and shorter survival.

Conclusion: Elderly patients with HCC have a worse prognosis compared to non-elderly ones. Such difference seems the consequence of undertreatment.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Age Factors
  • Aged
  • Aged, 80 and over
  • Carcinoma, Hepatocellular / diagnosis*
  • Carcinoma, Hepatocellular / mortality
  • Carcinoma, Hepatocellular / therapy*
  • Databases, Factual
  • Humans
  • Patient Care Planning / statistics & numerical data*
  • Practice Patterns, Physicians' / statistics & numerical data*
  • Prognosis
  • Retrospective Studies
  • Survival Rate
  • Treatment Outcome