The switch on the RAPper's necklace.

Mol Cell. 2006 Aug;23(4):451-5. doi: 10.1016/j.molcel.2006.07.026.

Abstract

The biosynthesis and export of LDL receptor-related proteins rely on specialized chaperones in the endoplasmic reticulum. Two recent papers in Molecular Cell by Fisher et al. (2006) and Lee et al. (2006) reveal a novel mechanism by which one of these chaperones, the receptor-associated protein RAP, accomplishes this task.

Publication types

  • Review

MeSH terms

  • Animals
  • Endoplasmic Reticulum / metabolism
  • Histidine / chemistry
  • LDL-Receptor Related Protein-Associated Protein / chemistry
  • LDL-Receptor Related Protein-Associated Protein / metabolism*
  • LDL-Receptor Related Proteins / metabolism

Substances

  • LDL-Receptor Related Protein-Associated Protein
  • LDL-Receptor Related Proteins
  • Histidine