Is the osmotically inactive sodium storage pool fixed or variable?

J Appl Physiol (1985). 2007 Jan;102(1):445-7. doi: 10.1152/japplphysiol.00614.2006. Epub 2006 Aug 17.

Abstract

Recently, there is renewed interest in the role of osmotically inactive Na(+) storage during Na(+) retention. Although it is well accepted that a portion of the total exchangeable Na(+) reservoir is osmotically inactive, there is current controversy as to whether the osmotically inactive Na(+) storage pool is fixed or variable during Na(+) retention. In this article, we analyze the current scientific evidence to assess whether the osmotically inactive Na(+) storage pool can be dynamically regulated. Our analysis supports the assertion that the osmotically inactive Na(+) storage pool is fixed rather than variable.

Publication types

  • Review

MeSH terms

  • Animals
  • Dogs
  • Humans
  • Osmosis / physiology
  • Potassium / metabolism
  • Rats
  • Skin / metabolism
  • Sodium / metabolism*
  • Water-Electrolyte Balance / physiology*

Substances

  • Sodium
  • Potassium