Inhibition of Angiogenesis by Vitamin D3 Analogues

Eur J Pharmacol. 1990 Mar 20;178(2):247-50. doi: 10.1016/0014-2999(90)90483-m.

Abstract

The effects of vitamin D3 and two analogues on embryonic angiogenesis were studied in 4.5-day-old chick embryo chorioallantoic membranes. The active metabolite of vitamin D3, 1 alpha,25-dihydroxyvitamin D3, and a synthetic vitamin D3 analogue, 22-oxa-1 alpha,25-dihydroxyvitamin D3, inhibited angiogenesis in a dose-dependent manner, the inhibition occurring in the picomolar range. In contrast, vitamin D3 was not effective. The results suggest that these two vitamin D3 analogues might be promising anti-angiogenic agents for controlling the angiogenesis which occurs in several pathological conditions, including tumor development.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Calcitriol / analogs & derivatives
  • Calcitriol / pharmacology
  • Chick Embryo
  • Cholecalciferol / pharmacology*
  • Neovascularization, Pathologic*

Substances

  • Cholecalciferol
  • Calcitriol
  • maxacalcitol